Philipp le Coutre Selected Research

nilotinib

7/2021	Correction to: Long-term outcomes with frontline nilotinib versus imatinib in newly diagnosed chronic myeloid leukemia in chronic phase: ENESTnd 10-year analysis.
1/2021	Long-term outcomes with frontline nilotinib versus imatinib in newly diagnosed chronic myeloid leukemia in chronic phase: ENESTnd 10-year analysis.
1/2019	Cost Effectiveness of the Third-Generation Tyrosine Kinase Inhibitor (TKI) Ponatinib, vs. Second-Generation TKIs or Stem Cell Transplant, as Third-Line Treatment for Chronic-Phase Chronic Myeloid Leukemia.
1/2018	Nilotinib.
8/2017	Impact of age on efficacy and toxicity of nilotinib in patients with chronic myeloid leukemia in chronic phase: ENEST1st subanalysis.
7/2017	Nilotinib first-line therapy in patients with Philadelphia chromosome-negative/BCR-ABL-positive chronic myeloid leukemia in chronic phase: ENEST1st sub-analysis.
2/2015	Vascular safety issues in CML patients treated with BCR/ABL1 kinase inhibitors.
1/2015	BCR-ABL1(+) acute myeloid leukemia: clonal selection of a BCR-ABL1(-) subclone as a cause of refractory disease with nilotinib treatment.
7/2014	Inhibition of c-Kit signaling is associated with reduced heat and cold pain sensitivity in humans.
12/2012	Off-target effects of BCR-ABL1 inhibitors and their potential long-term implications in patients with chronic myeloid leukemia.

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Philipp le Coutre Research Topics

Disease

51	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2022 - 01/2002
22	Philadelphia Chromosome 01/2020 - 10/2002
8	Leukemia 01/2020 - 10/2002
8	Neoplasms (Cancer) 10/2019 - 01/2007
7	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2016 - 04/2010
6	Blast Crisis (Blast Phase) 01/2018 - 03/2005
4	Primary Myelofibrosis (Myelosclerosis) 01/2020 - 01/2016
3	Disease Progression 01/2021 - 04/2014
3	Thrombocytopenia (Thrombopenia) 01/2016 - 01/2012
2	Pancreatitis 12/2019 - 01/2016
2	Exanthema (Rash) 01/2016 - 10/2002
2	Anemia 01/2016 - 01/2012
2	Neutropenia 01/2016 - 01/2012
2	Chromosome Aberrations (Chromosome Abnormalities) 02/2014 - 04/2010
1	Multiple Myeloma 01/2021
1	Splenomegaly 01/2020
1	Infections 01/2020
1	Myeloid Leukemia (Leukemia, Myelocytic) 10/2019
1	Hairy Cell Leukemia 01/2018
1	Diarrhea 01/2018
1	Prostatic Neoplasms (Prostate Cancer) 08/2017
1	Atherosclerosis 08/2017
1	Lymphocytosis 05/2016
1	Thrombocytosis (Thrombocythemia) 01/2016
1	Arterial Occlusive Diseases (Arterial Occlusive Disease) 01/2016
1	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2016
1	Atrial Fibrillation 01/2016
1	Pulmonary Hypertension 02/2015
1	Peripheral Arterial Occlusive Disease 1 02/2015
1	Residual Neoplasm 10/2014
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 10/2014
1	Pain (Aches) 07/2014
1	Pathologic Complete Response 02/2014
1	Coronary Artery Disease (Coronary Atherosclerosis) 06/2012
1	Hyperthyroidism 11/2010
1	Autoimmune Thyroiditis (Lymphomatous Thyroiditis) 11/2010
1	Hypothyroidism 11/2010
1	Headache (Headaches) 06/2010
1	Genetic Translocation (Chromosomal Translocation) 01/2010
1	Colorectal Neoplasms (Colorectal Cancer) 01/2007
1	Squamous Cell Neoplasms (Squamous Cell Cancer) 01/2007
1	Necrosis 01/2006
1	Brain Neoplasms (Brain Tumor) 03/2005
1	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 03/2005
1	Glioblastoma (Glioblastoma Multiforme) 03/2005
1	Body Weight (Weight, Body) 01/2004
1	Carcinoma (Carcinomatosis) 04/2003
1	Papillomavirus Infections 04/2003
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 04/2003

Drug/Important Bio-Agent (IBA)

34	Imatinib Mesylate (Gleevec)FDA Link 01/2022 - 01/2002
22	nilotinib FDA Link 07/2021 - 11/2007
21	Tyrosine Kinase InhibitorsIBA 01/2022 - 03/2005
8	Phosphotransferases (Kinase)IBA 12/2019 - 10/2002
7	Dasatinib (BMS 354825)FDA Link 01/2019 - 11/2010
5	bosutinibIBA 01/2022 - 01/2018
4	ponatinibIBA 01/2020 - 02/2015
4	bcr-abl Fusion ProteinsIBA 02/2008 - 01/2002
3	ruxolitinibIBA 01/2020 - 01/2016
3	Tyrosine (L-Tyrosine)FDA Link 01/2015 - 03/2005
3	Pharmaceutical PreparationsIBA 01/2007 - 10/2002
2	Lipase (Acid Lipase)FDA Link 12/2019 - 01/2016
2	Proteins (Proteins, Gene)FDA Link 10/2019 - 01/2010
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2010 - 01/2002
2	Messenger RNA (mRNA)IBA 03/2005 - 01/2004
1	Janus KinasesIBA 01/2020
1	Janus Kinase InhibitorsIBA 01/2020
1	asciminibIBA 12/2019
1	Adenosine Triphosphate (ATP)IBA 12/2019
1	NVP-BKM120IBA 12/2019
1	AntigensIBA 10/2019
1	EpitopesIBA 10/2019
1	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 10/2019
1	immunotoxin HA22IBA 01/2018
1	Immunotoxins (Immunotoxin)IBA 01/2018
1	Prednisone (Sone)FDA LinkGeneric 08/2017
1	Docetaxel (Taxotere)FDA Link 08/2017
1	anagrelide (Agrylin)FDA LinkGeneric 01/2016
1	Analgesics (Analgesic Drugs)IBA 07/2014
1	Biological ProductsIBA 07/2014
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2014
1	Proton Pump InhibitorsIBA 08/2012
1	HomoharringtonineIBA 10/2011
1	Oncogene Proteins (Oncogene Protein)IBA 10/2008
1	Irinotecan (Camptosar)FDA LinkGeneric 01/2007
1	Cetuximab (Erbitux)FDA Link 01/2007
1	Peptides (Polypeptides)IBA 01/2006
1	CytokinesIBA 01/2006
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 03/2005
1	Platelet-Derived Growth FactorIBA 03/2005

Therapy/Procedure

19	Therapeutics 01/2022 - 01/2002
6	Stem Cell Transplantation 01/2016 - 04/2010
3	Hematopoietic Stem Cell Transplantation 01/2021 - 10/2014
3	Transplantation 01/2014 - 04/2011
2	Drug Therapy (Chemotherapy) 01/2021 - 04/2003
2	Radiotherapy 01/2007 - 03/2005
1	Immunotherapy 10/2019
1	Aftercare (After-Treatment) 05/2016
1	Organ Transplantation 01/2014
1	Heart Transplantation (Grafting, Heart) 01/2014
1	Drug Tapering 01/2012